Selnick, Harold: search on Z-Library

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1

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

John W. Butcher, Nigel J. Liverton, Harold G. Selnick, Jason M. Elliot, Garry R. Smith, Andrew J. Tebben, David A. Pribush, John S. Wai, David A. Claremon

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 177 KB

english, 1996

2

Discovery of 6-(fluoro- 18 F )-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([ 18 F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Walji, Abbas M., Hostetler, Eric D., Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O'Malley, Stacey, Purcell, M

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.52 MB

english, 2016

3

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Stacey R. Lindsley, Keith P. Moore, Hemaka A. Rajapakse, Harold G. Selnick, Mary Beth Young, Hong Zhu, Sanjeev Munshi, Lawrence Kuo, Georgia B. McGaughey, Dennis Colussi, Ming-Chih Crouthamel, Ming-Ta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 170 KB

english, 2007

4

Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors

Young, Mary Beth, Barrow, James C., Glass, Kristen L., Lundell, George F., Newton, Christina L., Pellicore, Janetta M., Rittle, Kenneth E., Selnick, Harold G., Stauffer, Kenneth J., Vacca, Joseph P.,

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 350 KB

english, 2004

5

Encyclopedia of Reagents for Organic Synthesis || Lithium 2-Lithiophenoxide

Selnick, Harold G.

Year:

2001

Language:

english

File:

PDF, 72 KB

english, 2001

6

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle, Philippe G. Nantermet, Harold G. Selnick, Richard C.A. Isaacs, S.Dale Lewis, Bobby J. Lucas, Julie A. Krueger, Rominder Singh, Cynthia Miller-St

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 255 KB

english, 2003

7

The total synthesis of avermectin A1a

Danishefsky, Samuel J., Armistead, David M., Wincott, Francine E., Selnick, Harold G., Hungate, Randall

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 1.92 MB

english, 1989

8

P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold

Philippe G. Nantermet, Christopher S. Burgey, Kyle A. Robinson, Janetta M. Pellicore, Christina L. Newton, James Z. Deng, Harold G. Selnick, S. Dale Lewis, Bobby J. Lucas, Julie A. Krueger, Cynthia Mi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 297 KB

english, 2005

9

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Elliott, Jason M., Selnick, Harold G., Claremon, David A., Baldwin, John J., Buhrow, Susan A., Butcher, John W., Habecker, Charles N., King, Stella W., Lynch, Joseph J.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 443 KB

english, 1992

10

SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick, James C. Barrow, Georgia B. McGaughey, Sanjeev Munshi, Stacey R. Lindsley, Mary Beth Young, Phung L. Ngo, M. Katherine Holloway, Ming-Tai

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 540 KB

english, 2010

11

In vitro characterization of [3H]-T808 (tau PET tracer) binding in human brain tissues of Alzheimer's disease

Zeng, Zhizhen, Chen, Tsing-Bau, Miller, Patricia, O'Malley, Stacey, Connolly, Brett, Bennacef, Idriss, Selnick, Harold G., Pollack, Scott, Sur, Cyrille, Hostetler, Eric

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 261 KB

english, 2013

12

ChemInform Abstract: A Facile Three-Step Synthesis of 1,2-Amino Alcohols Using the Ellman Homochiral tert-Butylsulfinamide.

James C. Barrow, Phung L. Ngo, Janetta M. Pellicore, Harold G. Selnick, Philippe G. Nantermet

Journal:

Year:

2001

File:

PDF, 32 KB

2001

13

Total synthesis of (.+-.)-gnididione and (.+-.)-isognididione

Jacobi, Peter A., Selnick, Harold G.

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 1.13 MB

english, 1990

14

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1) †

Rajapakse, Hemaka A., Nantermet, Philippe G., Selnick, Harold G., Munshi, Sanjeev, McGaughey, Georgia B., Lindsley, Stacey R., Young, Mary Beth, Lai, Ming-Tain, Espeseth, Amy S., Shi, Xiao-Ping, Colus

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 124 KB

english, 2006

15

EARLY CLINICAL RESULTS AND PRECLINICAL VALIDATION OF THE O-GLCNACASE (OGA) INHIBITOR MK-8719 AS A NOVEL THERAPEUTIC FOR THE TREATMENT OF TAUOPATHIES

Smith, Sean M., Struyk, Arie, Jonathan, Daniel, Declercq, Ruben, Marcus, Jacob, Toolan, Dawn, Wang, Xiaohai, Schachter, Joel B., Cosden, Mali, Pearson, Michelle, Hess, Fred, Selnick, Harold, Salinas,

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 143 KB

english, 2016

16

Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1

James C. Barrow, Kenneth E. Rittle, Phung L. Ngo, Harold G. Selnick, Samuel L. Graham, Steven M. Pitzenberger, Georgia B. McGaughey, Dennis Colussi, Ming-Tain Lai, Qian Huang, Katherine Tugusheva, Amy

Journal:

Year:

2007

Language:

english

File:

PDF, 302 KB

english, 2007

17

A novel degradation in the avermectin series: A stereospecific osmylation reaction

Harold G. Selnick, Samuel J. Danishefsky

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 182 KB

english, 1987

18

Total synthesis of zincophorin

Danishefsky, Samuel J., Selnick, Harold G., Zelle, Robert E., DeNinno, Michael P.

Journal:

Journal of the American Chemical Society

Year:

1988

Language:

english

File:

PDF, 1.29 MB

english, 1988

19

Insights into activity and inhibition from the crystal structure of human O-GlcNAcase

Elsen, Nathaniel L, Patel, Sangita B, Ford, Rachael E, Hall, Dawn L, Hess, Fred, Kandula, Hari, Kornienko, Maria, Reid, John, Selnick, Harold, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J, Soiss

Journal:

Nature Chemical Biology

Year:

2017

Language:

english

File:

PDF, 773 KB

english, 2017

20

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective α1a-receptor antagonists

James C Barrow, Kristen L Glass, Harold G Selnick, Roger M Freidinger, Raymond S.L Chang, Stacey S O'Malley, Carla Woyden

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 155 KB

english, 2000

21

In vitro characterization of [3H]-T808 (tau PET tracer) binding in human brain tissues in Alzheimer's disease

Chen, Tsing-Bau, Zeng, Zhizhen, Miller, Patricia, O'Malley, Stacey, Connolly, Brett, Bennacef, Idriss, Selnick, Harold G., Pollack, Scott, Sur, Cyrille, Hostetler, Eric

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 152 KB

english, 2013

22

Bis heteroannulation. 7. Total syntheses of (.+-.)-gnididione and (.+-.)-isognididione

Jacobi, Peter A., Selnick, Harold G.

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 318 KB

english, 1984

23

Discovery of MK-8719, A Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Selnick, Harold, Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel, Ballard, Jeanine E., Marcus, Jacob Newman, Klein, Daniel J., Wang, Xiaohai, Pearson, Michelle, Savage, Mary J., Kaul, Ramesh, LI

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.04 MB

english, 2019

24

Selective α1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

Philippe G Nantermet, James C Barrow, Harold G Selnick, Carl F Homnick, Roger M Freidinger, Raymond S.L Chang, Stacey S O'Malley, Duane R Reiss, Theodore P Broten, Richard W Ransom, Douglas J Pettibon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 144 KB

english, 2000

25

The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides

Danishefsky, Samuel J., Selnick, Harold G., Armistead, David M., Wincott, Francine E.

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 268 KB

english, 1987

26

Pharmacological Modulation of IKs: Potential for Antiarrhythmic Therapy

Salata, Joseph, Selnick, Harold, Lynch Jr., Joseph

Journal:

Current Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 308 KB

english, 2004

27

In vitro study on [3H]THK523 binding to brain tissues of Alzheimer's disease

Zeng, Zhizhen, Chen, Tsing-Bau, Miller, Patricia, Connolly, Brett, Selnick, Harold G., Pollack, Scott, Sur, Cyrille, Hamill, Terence

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 126 KB

english, 2012

28

The synthesis of dihydrothieno[2,3-b]thiophenes by a metal-halogen exchange initiated intramolecular acylation

Harold G. Selnick, Ellen M. Radzilowski, Gerald S. Ponticello

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 231 KB

english, 1991

29

Preparation and trapping of 3-lithium-O-lithiophenoxide

Harold G. Selnick, Michelle L. Bourgeois, John W. Butcher, Ellen M. Radzilowski

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 236 KB

english, 1993

30

Suppression of Lethal Ischemic Ventricular Arrhythmias by the Class III Agent E4031 in a Canine Model of Previous Myocardial Infarction

Lynch, Joseph J., Heaney, Lisa A., Wallace, Audrey A., Gehret, John R., Selnick, Harold G., Stein, Robert B.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1990

File:

PDF, 986 KB

1990

31

The total synthesis of the aglycon of avermectin A1a

Danishefsky, Samuel J., Armistead, David M., Wincott, Francine E., Selnick, Harold G., Hungate, Randall

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 423 KB

english, 1987

32

Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase ‡

Barrow, James C., Stauffer, Shaun R., Rittle, Kenneth E., Ngo, Phung L., Yang, ZhiQiang, Selnick, Harold G., Graham, Samuel L., Munshi, Sanjeev, McGaughey, Georgia B., Holloway, M. Katharine, Simon, A

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 380 KB

english, 2008

33

Cardiac Electrophysiologic and Inotropic Actions of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents in Anesthetized Dogs

Wallace, Audrey A., Stupienski, Raymond F., Brookes, Lynne M., Selnick, Harold G., Claremon, David A., Lynch, Joseph J.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1991

File:

PDF, 614 KB

1991

34

Evolution of Tertiary Carbinamine BACE-1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

Philippe G. Nantermet, Hemaka A. Rajapakse, Mathew G. Stanton, Shaun R. Stauffer, James C. Barrow, Allison R. Gregro, Keith P. Moore, Melissa A. Steinbeiser, John Swestock, Harold G. Selnick, Samuel L

Journal:

Year:

2009

Language:

english

File:

PDF, 399 KB

english, 2009

35

Cover Picture: Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 (ChemMedChem 7/2007)

James C. Barrow, Kenneth E. Rittle, Phung L. Ngo, Harold G. Selnick, Samuel L. Graham, Steven M. Pitzenberger, Georgia B. McGaughey, Dennis Colussi, Ming-Tain Lai, Qian Huang, Katherine Tugusheva, Amy

Journal:

Year:

2007

File:

PDF, 31 KB

2007

36

A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

James C Barrow, Phung L Ngo, Janetta M Pellicore, Harold G Selnick, Philippe G Nantermet

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 85 KB

english, 2001

37

Potent thrombin inhibitors via a 20-membered ring olefin metathesis macrocyclization

Philippe G. Nantermet, Harold G. Selnick

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 195 KB

english, 2003

38

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Liverton, Nigel J., Butcher, John W., Claiborne, Christopher F., Claremon, David A., Libby, Brian E., Nguyen, Kevin T., Pitzenberger, Steven M., Selnick, Harold G., Smith, Garry R., Tebben, Andrew, Va

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 335 KB

english, 1999

39

Bis-heteroannulation. 16. A synthetic approach to geigerin

Jacobi, Peter A., Touchette, Kim M., Selnick, Harold G.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 1.05 MB

english, 1992

40

Effects of New and Potent Methanesulfonanilide Class III Antiarrhythmic Agents on Myocardial Refractoriness and Contractility in Isolated Cardiac Muscle

Baskin, Elizabeth P., Serik, Carolann M., Wallace, Audrey A., Brookes, Lynne M., Selnick, Harold G., Claremon, David A., Lynch, Joseph J.

Journal:

Journal of Cardiovascular Pharmacology

Year:

1991

File:

PDF, 667 KB

1991

41

β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites

Georgia B. McGaughey, Dennis Colussi, Samuel L. Graham, Ming-Tain Lai, Sanjeev K. Munshi, Philippe G. Nantermet, Beth Pietrak, Hemaka A. Rajapakse, Harold G. Selnick, Shaun R. Stauffer, M. Katharine H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 240 KB

english, 2007

42

Enynones in organic synthesis. I. Spiroannulation by tandem oxy-cope rearrangement-electrocyclic ring closure

Peter A. Jacobi, Lisa M. Armacost, Joseph I. Kravitz, Michael J. Martinelli, Harold G. Selnick

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 288 KB

english, 1988

43

Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists

James C Barrow, Philippe G Nantermet, Harold G Selnick, Kristen L Glass, Phung L Ngo, Mary Beth Young, Janetta M Pellicore, Michael J Breslin, John H Hutchinson, Roger M Freidinger, Cindra Condra, Jer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 180 KB

english, 2001

44

A systematic degradation of zincophorin: a stereoselective synthesis of the C17-C25 fragment

Zelle, Robert E., DeNinno, Michael P., Selnick, Harold G., Danishefsky, Samuel J.

Journal:

Journal of Organic Chemistry

Year:

1986

Language:

english

File:

PDF, 747 KB

english, 1986

45

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α 1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

Barrow, James C., Nantermet, Philippe G., Selnick, Harold G., Glass, Kristen L., Rittle, Kenneth E., Gilbert, Kevin F., Steele, Thomas G., Homnick, Carl F., Freidinger, Roger M., Ransom, Rick W., Klin

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 329 KB

english, 2000

46

In vitro study on [3H]THK523 binding to brain tissues of Alzheimer's disease

Zhizhen Zeng, Tsing-Bau Chen, Patricia Miller, Brett Connolly, Harold G. Selnick, Scott Pollack, Cyrille Sur, Terence Hamill

Journal:

Alzheimer's & Dementia

Year:

2012

Language:

english

File:

PDF, 138 KB

english, 2012

47

ChemInform Abstract: Preparation and Evaluation of 1,3-Diaminocyclopentane-Linked Dihydropyrimidinone Derivatives as Selective α1a-Receptor Antagonists.

James C. Barrow, Kristen L. Glass, Harold G. Selnick, Roger M. Freidinger, Raymond S. L. Chang, Stacey S. O'Malley, Carla Woyden

Journal:

Year:

2000

File:

PDF, 41 KB

2000

48

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide

Selnick, Harold G., Liverton, Nigel J., Baldwin, John J., Butcher, John W., Claremon, David A., Elliott, Jason M., Freidinger, Roger M., King, Stella A., Libby, Brian E., McIntyre, Charles J., Pribush

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 100 KB

english, 1997

49

9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors

Stauffer, Kenneth J., Williams, Peter D., Selnick, Harold G., Nantermet, Philippe G., Newton, Christina L., Homnick, Carl F., Zrada, Matthew M., Lewis, S. Dale, Lucas, Bobby J., Krueger, Julie A., Pie

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 223 KB

english, 2005

50

The total synthesis of zincophorin

Danishefsky, Samuel J., Selnick, Harold G., DeNinno, Michael P., Zelle, Robert E.

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 815 KB

english, 1987

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